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Procter & Gamble Develop and Market First Fluoride Toothpaste

The research team produced a cavity-preventing toothpaste prototype by 1952 and proceeded to run clinical trials on 1,500 children and 400 adults in the area. After demonstrating that half of the participants showed a significant decrease in dental caries, Procter & Gamble released Crest toothpaste in 1956.